Nat is a Neurologist who does not only treat the physical diseases of his patients, but also their personal problems. He also uses various women from different backgrounds and with different personalities for his case study who have only one thing in common. Each of them is in dire need of some romance. While these women reveal their own secrets in regards to their past husband, they also make a bet as to who'll marry first of them.
Aoey begins a new job where she unfortunately begins on rocky terms with her new boss. Her colleague Ig refers her to a local gym to burn off the frustration through exercise, where she meets an attentive and caring physical trainer, Miriam.
Tata and Ryu are overwhelmed with the responsibilities of raising twins. To make matters worse, Lookmai has falsely told her many suitors that she lives at Tata's house, resulting in an influx of unwanted guests on an already stressed house. Jane ends her relationship with Ton and unexpectedly connects with Saifah at a cafe. Nat and Boy adopt a dog!
Tata enlists the help of Nat and Aoey to investigate where Ryu keeps disappearing to. Lookmai and Jeff, two pros at chatting online with a handful of partners, finds enjoyment in each other's company in-person.
Kluay celebrates her engagement with friends but encounters an old rival. Jane visits Saifah at his event where Lin also makes a guest appearance.
Piengkwan schedules a non-traditional appointment with Dr. Nat for some relationship advice. Aoey opens up to Miriam about the restraints she feels in their relationship.
Jane and Lookmai join Lin, Saifah and Jeff on a work trip to promote a hotel venue. Nat begins to lose patience with Dummy as an unwanted house guest.
Nat struggles with the major personality differences between him and Boy. Kluay continues to plan her wedding but is startled when she realizes her newfound enemy is working with her fiancé, Ton.
The ladies cross paths and collide with Piengkwan at the GG Boy Event leaving relationships in turmoil.
Shin confronts Piengkwan about the reality of their relationship. The Wake Up gang says their final goodbyes to Ton.
As the dust settles around the Wake Up gang, Tata and Ryu celebrate the 6 month "birthday" of their twins. Piengkwan is presented with an opportunity to make amends.
Complete episode guide for Wake Up Ladies: The Series with detailed information about every season and episode including air dates, summaries, ratings, and streaming availability in Spain.
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