Andrea Fanti loses his memories of the last twelve years of his life because of a cerebral trauma, and, for the first time, he finds himself not to be the smartest, renowned medic as usual, but a simple patient. Without the memories from his life, the man falls in an unknown world where loved ones are strangers, and the hospital becomes the only place where he truly feels at home. Inspired to the real life of Doctor Pier Dante Piccioni.
Professor Andrea Fanti, brilliant Head of Diagnostic Medicine, sees his life turned upside down when the father of a dead patient shoot him in the head. Andrea survives the shot, but loses the memories from the last twelve years of his life. When he wakes up from coma he struggles recognizing his collegues, his family and the man he was before.
Andrea is hospitalized in the Diagnostic Medicine ward in the hope that, over time, the most familiar place will help him recover his memories. Giulia follows his rehabilitation, but she finds herself dealing with a different man than the one she knew. And while Andrea tries to deal with his new condition, he lets himself be involved in the medical case of his roommate Jacopo, a boy with a complex pathology and an unspeakable secret.
Andrea returns to the ward as an assistant to the residents, who until a few weeks before were terrified of him and now are struggling to get used to the unexpected reversal of roles. While he tries to win back his ex-wife, the collaboration with Giulia on the case of a young manager will prove difficult and full of surprises.
The arrival of a particularly important patient for Giulia exasperates the competition among the residents, giving Andrea the opportunity to really get to know them. In the meantime, he involves the department in finding his email account's password that could help him rebuild a fundamental part of his past, but that someone wants to hide from him at all costs.
Giulia takes Andrea back to the hospital for a patient who asks to be examined exclusively by him, but who's unaware of his current conditions. However, a mistake caused by his amnesia puts all the residents under pressure. Meanwhile, Alba is forced to face the resentment she feels towards her mother.
A special episode set ten years earlier. Andrea, still an enthusiastic doctor with his family intact, for the first time has the opportunity to make a career leap. Keeping everything together, however, is not easy: the competition he suddenly finds himself involved in with his colleague Marco risks making him lose sight of who he really is.
The arrival in the hospital of Carolina, struck by a mysterious pathology, causes a series of conflicts between Andrea and Agnese that they must overcome together for the sake of their daughter. The attention of the young residents, on the other hand, is catched by an eye-catching influencer, and Alba cannot hide her jealousy for Riccardo.
In an attempt to recover his role as a father and help Carolina recover from her illness, Andrea returns to court Agnes. An annoying headache makes Gabriel struggle with treating a patient, while Elisa and Riccardo have to deal with a wanna-be astronaut.
Andrea is certain that he has finally broken through Agnese's heart and, in the wake of romanticism, proposes to organize a wedding in the hospital for a patient in critical condition. Meanwhile, an unexpected proposal from Gabriel upsets the balance within the group of residents.
A secret from Lorenzo's private life revealed by a patient creates amazement throughout the ward. Meanwhile, Gabriel and Elisa must strive to reconstruct the life of an elderly patient who seems to remember nothing about himself, but who repeatedly utters a single word.
The discovery of the medical record of the patient dead by mistake makes Andrea trying and reconstruct what happened before the shot that erased his memories. Marco, responsible for that death, and Agnese are not very cooperative. Alba and Riccardo struggle to re-establish their relationship and even between Gabriel and Elisa things get complicated.
A train accident transforms the Diagnostic Medicine ward into a makeshift emergency room. All doctors are called upon to do their utmost to deal with the emergency. Among the injured, a girl reopens an important chapter in Riccardo's past, which he believed to be forever closed.
The arrival in the hospital of Elisa's older sister, a nice and charming actress, makes the young resident inexplicably even more sour and grumpy. Andrea continues to dig through the years that the amnesia has erased, while Agnese is unable to hide her jealousy for the growing closeness between Giulia and the doctor.
Lorenzo is once again struggling with her ex, Chiara, when the girl is hospitalized for an overdose. Marco and his wife feel increasingly threatened by the research that Andrea is carrying out on Satonal, the experimental drug that seems to have caused several deaths. Gabriel, on the other hand, has to explain to his community that he plans to stop.
Andrea finds himself in the eye of the storm when a former resident accuses him of falsifying the results of a pharmaceutical trial: unable to defend himself due to amnesia, he seeks confirmation in the people close to him. Meanwhile, Lorenzo has to fight to get Chiara on the transplant list, and Agnese has a sudden illness.
Agnese's conditions worsen rapidly and Andrea finds the support of the whole department to try to discover the disease she suffers from. But the accusations brought against him of his involvement in the falsification of results of a pharmaceutical trials risk take him away from the hospital for good.
February 2020. Doc is determined to keep his team together and not let it fall apart: Giulia wants to move to Genoa, Lorenzo will perhaps leave medicine, Gabriel is leaving for Ethiopia, and Elisa also no longer seems interested in practicing at the hospital because she wants to spend a year on tropical diseases and join her boyfriend. Even Carolina doesn't want to think about Diagnostic Medicine, much to the chagrin of her father, who in the meantime doesn't seem to want to give up on Agnes. Giulia discovers she got pregnant after a night with Lorenzo. Cecilia Tedeschi, an infectious disease specialist and a study partner of Andrea and Agnese, arrives at the hospital. Meanwhile, a new virus from China comes to upset plans.
Months after the pandemic, Andrea's ward is reopened but someone is missing: Lorenzo is no longer there since he died in March 2020 due to COVID-19. Andrea left the ward to visit elderly people outside the hospital, occasionally helped by Riccardo. The hospitalization of Giacomo, a health worker, after what appears to be a hysterical attack is the first case under the direction of the new Chief. Lorenzo's death causes create concern, and an investigation threatens to reveal that he was patient zero. Meanwhile, Gabriel still intends to leave Italy. After losing her child, Giulia is increasingly determined to leave for Genoa once the investigation is over. Damiano Cesconi arrives in the department to replace Lorenzo. Doc decides he wants be the Chief once again and dreams of suffocating Lorenzo to the point of killing him, although it is not clear if it is only a dream or there is something true...
Doc faces his first day as Chief. New responsibilities to manage, without ever forgetting the patients; avoid the closure of the department, and guide three new residents.
The "new memory" of Doc, hyper-busy, upsets the balance of the department: Agnese fears that it could destabilize Andrea, while Damiano is worried about how it could impact Giulia.
Doc is looking for new memories, perhaps sensing "the sail" to follow. Giulia faces the problems of the department, and those of her career. A famous travel blogger ends up under Doc's care.
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While the investigation conducted by Caruso gets to the bottom and starts unraveling the secrets of the pandemic, Andrea faces a difficult choice: in order to be the Chief again he has to take some exams, but if he fails them he won't be allowed to be a doctor anymore. Carolina, who bonded so much with Riccardo during the emergency, ponders if she'd like something more from him than friendship.
Dealing with the case of a young tennis phenomenon, Andrea is forced to wonder if it is worth stopping being "Doc" to pursue the role of Chief. In the meantime, Carolina suffers in seeing Riccardo with Alba. Gabriel does not show up for the appointment Enrico set up for him with the new psychologist at the hospital, Lucia Ferrari.
Doc finds himself in direct competition with the new Chief and takes several risks, but he takes the opportunity to involve and help Agnese too, who had to leave the position of medical director and go back to being a doctor.
While a little war breaks out between Doc and doctor Valenti over Carolina, Doc faces the case of a boy with overbearing parents and is forced to question himself as a father.
Silvia's case closely involves Enrico too, as some of his past finally emerges. While Caruso's tests show more and more the actual intent of putting Doc in trouble, Cecilia starts finding out the team's secrets.
Back to the first months of the first wave, to finally uncover the secret that Doc and his team hide about what happened during those months of emergency and that seems to have definitely broken the relationship between Carolina and his father.
In order to cure an imprisoned mother who allegedly attempted to kill her own daughter, Doc must fight the prejudice of the entire hospital, in the exact same moment he becomes the main target of the investigation. Doc and Agnese are suddenly brought closer by this new situation, but in the meanwhile Damiano has found out a compromising proof on Doc and the team, and now he must choose which side he's on.
While our doctors are forced to take care of a patient that they would have never wanted to see hospitalized, the fracture between Doc and Carolina widens more and more, and Andrea must face a reckoning with himself: is he up to the task as the others expect from him? Or is it time to give up?
Agnese is surprised to find Manuel's mother hospitalized, the child she has in foster care with Davide, and with whom things don't seem to go too well. Agnese will have to question everything she thinks she knows, just when Andrea seems to want to be closer than ever. While Damiano's choices seem to open an insanable rift between him and Giulia, Gabriel finally decides to open up with the psychologist.
It is the day of the simulation for Doc as Chief: Andrea goes back to wearing the lab coat for one day, but a sudden IT blackout of the hospital systems forces him to make a series of risky choices.
While the doctors are busy solving the delicate case of a deafblind boy, Cecilia makes Doc an unexpected offer, triggering the jealousy of Agnese and Giulia. Meanwhile, Riccardo discovers something about Doc that puts him in a deep crisis. Gabriel makes a shocking proposal to Elisa, putting her in front of a difficult choice.
Giulia is forced to reckon with her bulky mother when her partner is hospitalized in the throes of an inexplicable syndrome. Just as Doc appears to be about to be Chief once again, Cecilia discovers something compromising about him.
Close to become Chief once again, Doc is forced to make a painful confession in front of the whole department. As doctors try to save the life of a young soldier with inexplicable symptoms, Agnese begins to investigate.
Locked in the hospital in a forced quarantine, the doctors are engaged in a race against time to stop a multidrug-resistant bacterium that has infected them all. Doc proposes a drastic and risky solution, but it is Giulia who has to decide.
Doc's search is finished: Andrea has perhaps found his "sail". Meanwhile, a baker is hospitalized with strange symptoms. While Riccardo faces a critical case, Federico is under pressure.
A new memory disorientates Andrea: his memory seems to suggest something to him. In the ward, another girl refuses chemotherapy, while Andrea takes care of a well known patient.
After the latest discoveries, Doc sees some certainties about his past collapse. He looks to Giulia for help, but she is confused. In the ward, Martina has to show off her talent with a patient.
The therapy sessions with Enrico seem to have sudden side effects on Doc, who sees his ability to care for patients questioned. And while Agnese seizes the opportunity to nip his research into the past, Giulia is convinced that Andrea must not give up.
Doc finally knows how to track down the woman he's looking for, but he must first find the courage to do it. Meanwhile, Riccardo finds himself dealing with the case of an undisciplined personal trainer.
The fear of discovering the terrible secret lost in his mind pushes Doc to move away from his department. Meanwhile, Enrico has to face the constant assaults of Barbara, Doc's assistant.
Doc and the team must face a difficult challenge: find the diagnosis for a patient before the artificial intelligence does. Meanwhile, Martina and Agnese are called to deal with complex choices.
Agnese's words have created a rift between her and Andrea, who also has to deal with the distance from Giulia, who is traveling to Rome for her research. The situation at the hospital is at its limit: Teresa has to work miracles to find a place for Diana's daughter, a woman Andrea met again after years, hospitalized despite her mother's doubts.
A violent earthquake causes panic at the Ambrosiano, and Lin fears that something may have happened to his family. Ric comes to a decision on the proposal made by Laura, a paralympic swimmer. Federico has to carry out an operation he doesn't feel ready for.
The deadline for submitting the research is getting closer and closer, but Giulia seems to have her mind somewhere else entirely. Even Doc struggles to manage his thousand commitments: there's the meeting with the investors, and then there's Carolina, in town for a few days. However, everything risks being overshadowed when Lin's sister is hospitalized.
Giulia has to make a decision about her personal life that will also have consequences on her career. And while Martina faces the most difficult exam of her life, and Damiano delicately takes care of Elisabetta, Riccardo deals with a case that will force him to deal with Alba's ghost.
March 2011: Andrea is forced to deal with Agnese's illness, but unexpected news from America rekindles hopes. At the hospital, the new Chief struggles with a difficult diagnosis, which will force someone to make a terrible compromise.
The moment of truth has arrived. While Federico faces his last day at the Ambrosiano, and Martina makes a decision that leaves the rest of the team stunned, Doc has to deal with the truth Agnese told him, forcing him to change his perspective on his past.